Initial translocations are inherently risky due to uncertainty about species-specific responses to novel environments and the ability to manage known and potential threats. Predator free environments remove predation risk but there are usually many other risks to translocation failure. Proactively identifying these risks and implementing a range of release protocols can improve translocation outcomes. We conducted initial translocations of two species to predator free environments and used radiotracking to test release protocols to increase translocation success. We identified post-translocation hyperdispersal as a risk to the first translocation of the crest-tailed mulgara (Dasycercus cristicauda), a carnivorous marsupial, and tested temporary confinement in pens and releasing females with pouch young. Temporary confinement did not influence survival of mulgara but did influence dispersal behaviour with 42% immediate release animals hyperdispersing compared to 29% temporary confinement animals. Releasing females with pouch young led to an accelerated increase in the translocated population from 9 to 58 individuals within 4 months. We identified availability of suitable nesting sites as a risk to the first translocation of greater stick-nest rat (Leporillus conditor) to our study site. These native rodents build elaborate permanent stick nests around perennial shrubs or under rocky overhangs that are passed on to successive generations. We tested the provision of artificial nest structures in assisting rats to establish nests by comparing the use of self-built nests with two artificial nest designs. Proactive identification of these risks and implementing release protocols under an experimental framework assisted with understanding their contribution to translocation success.