Phytotherapy plays an important role in traditional medicine, but there are concerns about the risks posed by these plants, especially if consumed above permitted limits. In Paraguay, the aquatic species Eichhornia crassipes, commonly known as water hyacinth, is used for medicinal purposes; however, it is recognized worldwide as a phytoremediator, with a lead removal capacity exceeding 70% in aquatic systems. Therefore, its consumption could represent a direct exposure route for consumers. The objective of this study is to evaluate the lead concentration in E. crassipes plants, focusing on two groups: plants sold for consumption and plants from protected areas. Whole plants will be collected from municipal markets, and a survey of vendors will be conducted during the collection process. Plants obtained from protected areas will be used to establish an experimental baseline of lead concentration according to the conditions of each ecoregion. Lead concentration determination will be performed using flame atomic absorption spectrophotometry (AAS) according to SW-846 Method 7000 B, with prior digestion using EPA Method 3052. The diversification of lead exposure sources and the use of plants as a traditional product without mechanisms to guarantee their quality highlights the need to explore the implications associated with the medicinal use of certain species. This includes characterizing the marketing process, popular knowledge of therapeutic benefits, conditions of use, and overlap with other properties such as the accumulation of environmental contaminants. This is because these plants are not obtained from planned crops but are extracted from the natural environment, considering that they are relatively common and highly invasive species without very strict environmental requirements.