Increasingly we are hearing about the benefit of creating a global framework and set of indicators to assess the health and restoration outcomes of ecosystems and species. Being able to measure outcomes is considered foundational to the United Nations Sustainable Development Goals and Kunming-Montreal Global Biodiversity Framework (GBF) that was adopted at COP15. Measuring biophyscial condition is relatively straightforward, epitomised by progress with the IUCN Red List of Threatened Species and IUCN Red List of Ecosystems. However with increasing interest in and recognition about the importance of human-nature connections in contemporary and future conservation pursuits, especially those of Indigenous and Local Peoples who have strong, enduring connections to place, these priority lists tend to overlook the importance of co-evolution and co-dependencies between species, ecosystems and human cultural practices. This discussion will centre around the question - can we establish a framework to guide a new Red List of Biocultural Systems, that, like the IUCN Red List of Threatened Species, could be an information source on the global extinction risk status of linked bio-cultural systems. The International Society of Ethnobiology Conference in Cairns offers a unique gathering of practitioners, researchers and policy makers who are well positioned to brainstorm the parameters of a potential framework, if indeed one can be produced that is ethical and flexible enough to capture the most remote and disparate places and communities. Please join us and lets see if we can come up with a framework for an international Red List of Biocultural Systems!